Yes, that's the crux of depression. Spent months on and off in my 20s feeling like that before eliminating drugs and alcohol from my life (except nicotine albeit in chewing gum form lol) and learning a vast array of coping strategies, all of which (20 years later) started to finally shift it from the majority of my life.
Most anti-malarials are pretty nasty (chloroquine included). 20 years in a malarial region and very soon stopped taking any prophylactics. The downsides pretty much wiped out the benefits from reduction in risk.