Pacha is open on friday and saturday, good nights, not many people but still busy. if you want to party on a wednesday you can go to Grial which is in the same avenue as Pacha. lola's should be open as well during the weekend and you must check out Blu if there is any good parties (like cocoon).
One thing a suggest you that you can also do is visit the island, i live there and oh my! its beautiful, rent a car and get lost in the island is the best way to see its beauty!
enjoy it!