you cant go wrong with Pacha mate, or El Divino. but Pacha is probably the best club in the world. they have amazing nights every night of the week and the music policy is quite diverse depending on what nite you go to, Def Mix on a sat is new york house, Release Yourself on a mon with Roger Sanchez is electro but also quite deep and tribal, Defected on a Tues is funky but not too funky, and they have live percussion from Shovell which is awesome, Subliminal on a weds is a bit of everything really with Erick Morillo, F*** me im Famous or Renaissance on Thurs, both amazing and finishing the week is Pure Pacha with Mr Pete Tong, weds and fri are prob the busiest Pacha nights.
so i would have to say Pacha is the best, try and get there at least once. and Space is a great place to go to. you cant really fail