Do you mean for shopping, clubbing, drinking, restaurants???
Covent Garden is good for shopping, nice bars, restaurants, can get a bit touristy at wkends but apart from that it's nice and quite picturesque. The End club is close to Covent Garden as well which is always a good night.
Soho has got a lot of gay bars, sex shops but it's got a real cosmo feel to it in summer, you can sit outside the bars and have a drink and pretend you're in the Med.........well kind of
It depends what you're after really. Notting Hill has got nice bars/restaurants, Knightsbridge is all fancy if you want to to visit all the swanky clothes shops, Kensington is nice, there's loads of places. Wherever you stay you won't be far from the action
